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CRISPR Genome Editing: From high-throughput screening to disease models

Date Thursday, September 22 - Friday, September 23, 2016
Location Lundsgaard Auditorium, Panum Institutet, Nørre Alle 20, Copenhagen N
Organizers Yonglun Luo, Cord Brakebusch, Tuula Kallunki (Danish Society for Bicohemistry and Molecular Biology (DSBMB)

Program

September 22, 2016

9.15-10.00

Registration and poster mounting

10.00-10.15

Welcome and opening of the meeting: Prof. Ulla Wewer, Dean of Health and Medical Sciences, Copenhagen University

10.15-10.20

Organizers welcome and some practicalities: Tuula Kallunki, Chairperson, Danish Society for Biochemistry and Molecular Biology

Session I: Session chair Tuula Kallunki, Danish Cancer Society Research Center, Copenhagen, Denmark

10.20-10.55

"CRISPR screening of the regulatory genome "Richard Sherwood, Hubrecht Institute and UMC Utrecht, Utrecht, the Netherlands; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA

10.55-11.30

"CRISPR-based functional genetic screens for enhancer elements" Reuven Agami, Erasmus MC, Rotterdam University, Rotterdam, the Netherlands and the Netherlands Cancer Institute, Amsterdam

11.30-12.05

"CRISPR/Cas9 somatic multiplex mutagenesis for high-throughput functional cancer genomics in mice" Roland Rad, Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

12.05-13.00

Lunch break/exhibition/posters

Session II: Session chair Yonglun Luo, Department of Biomedicine, Aarhus University, Aarhus, Denmark

13.00-14.00

Keynote talk: "Genome editing using CRISPR-Cas systems" Feng Zhang/Jonathan Gootenberg, Broad Institute, Harvard &MIT, Boston, MA, USA 

14.00-14.35

"Tune DNA damage repair pathways with recombinant Cas9 proteins", Yonglun Luo, Department of Biomedicine, Aarhus University, Aarhus, Denmark

14.35-15.10

"Hit and seek: Finding the breaks in a precisely broken genome" Eric Bennett, Departments of Cellular and Molecular Medicine and Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

15.10-15.40

Coffee break/exhibition/posters

Session III: Session chair Eric Bennet, Departments of Cellular and Molecular Medicine and Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

15.40-16.15:

"Chromosome Engineering with Cas9 in vivo" Allan Bradley, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

16.15-16.50

"Genome engineering to transform xenotransplantation a clinical reality"Luhan Yang, Department of Genetics, Harvard Medical School, Boston, MA, USA

 

September 23, 2016

Session IV: Session chair Cord Brakebusch, Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark

9.00-9.50

Keynote talk: "Biallelic genome editing of human pluripotent stem cells at scale " Bill Skarnes, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK

9.50-10.25

"Lentiviral delivery of genome editing tool kits" Jakob Giehm Mikkelsen, Department of Biomedicine, Aarhus University, Aarhus, Denmark

10.25-11.00

"Genome editing of cancer cell lines" Morten Frödin, BRIC, University of Copenhagen, Copenhagen

11.00-11.30

Coffee break/exhibition/posters

Session V: Session chair Mette Vixø Vistesen, Danish Cancer Society Research Center, Copenhagen, Denmark

11.30-12.05

"Gene editing in mouse zygotes and human iPS cells" Ralf Kühn, Max-Delbrück-Center for Molecular Medicine, 13125, Berlin, Germany.

12.05-12.40

"Applications of CRISPR-mediated gene editing in stem cell research", Kristine Freude, Group of Stem Cells and Embryology, Dept. of Vet. Science, University of Copenhagen, Copenhagen

12.40-14.00

Lunch break/exhibition/posters

Session VI: Session chair Julian Geiger, Department of Science and Environment, Roskilde University, Roskilde, Denmark

14.00-14.35

"CRISPR/Cas9-induced disruption of gene expression in mouse embryonic brain" Mihail Sarov, Max Planck Institute of Molecular Cell Biology and Genetics (MPI?CBG), Dresden, Germany

14.35-15.10

"Designer nucleases in modification of large animal primary cells" Nikolai Klymiuk, Chair for Molecular Animal Breeding and Biotechnology (MABB), LMU Munich, Munich, Germany

15.10-15.45

"Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes" Wolfgang Wurst, German Research Center for Environmental Health, Institute of Developmental Genetics, Helmholtz Zentrum München, Germany

15.45-16.00

Closing remarks: Yonglun Luo, Department of Biomedicine, Aarhus University, Aarhus, Denmark

Registration

Registration has ended.

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