| Past events:
Third DAPSOC Symposium ’Systems Biology and Proteomics’.
The 3rd DAPSOC Symposium ’Systems Biology and Proteomics’ was held at the University of Southern Denmark at Odense on Dec. 4, 2007. This symposium turned out to be the largest DAPSOC Symposium to date, with more than 120 delegates and an exhibition with 14 companies. The Symposium was held in the recently added conference section of the University of Southern Denmark that provided an excellent environment for lectures, poster sessions and exhibitions.
After a short introduction by DAPSOC president Ole N. Jensen (Univ. Southern Denmark), the Symposium was kicked off with a plenary lecture by Ruedi Aebersold (ETH Zürich, CH) who described several targeted mass spectrometry approaches to bring proteomics to the systems biology level. The following speaker, Kristian Helin (BRIC, Copenhagen University, DK) emphasized the need for a reductionistic view to study the molecular implications of protein methylation and demethylation in epigenetics and cancer research. Connie Jimenez (Free University, Amsterdam, NL) then introduced her work in oncoproteomics and the utility and reproducibility of sample prefractionation of tumor tissue prior to proteomic analysis by mass spectrometry and bioinformatics.
The next session emphasized proteomics in agricultural sciences. Klaas Jan Van Wijk (Cornell Univ., New York) described his recent work on proteomics of plant organelles in maize using various protein and peptide separation techniques and several different ways to quantify proteins by mass spectrometry. Emøke Bendixen (Aarhus University, DK) presented how proteomics workflows are used in pig breeding research, including nice examples of gut proteomics and integrative approaches to understand animal physiology.
The last session was kicked off by Kasper Lage (Technical University of Denmark) who demonstrated how computational techniques and data mining methods can be integrated to derive biological function and predict disease genes from biological and bibliographical databases. Kamilla Pedersen (Aarhus University, DK) led the audience through a ‘mystery case’ to identify D. melanogaster genes involved in pathogenesis, including both genomics and proteomics technologies. The last speaker, Kåre Lehmann (Aalborg University, DK) gave an overview of large-scale techniques for gene expression analysis, including efficient and economic SAGE methods adapted for the new 454 and Solexa high-throughput sequencers.
During coffee breaks and the lunch break there was ample time for discussions among the participants, speakers and exhibitors. The following companies were exhibiting their products: Advion, Bruker Daltonics Scandinavia, Denator AB, Dionex Denmark A/S, GE Healthcare Life Sciences, Holm & Halby, Krüger Aquacare A/S, Nonlinear Dynamics, Olympus Danmark A/S, Proxeon A/S, Qiagen Nordic, Roche Diagnostics A/S, Sigma-Aldrich Danmark, ThermoFisher Scientific. The DAPSOC committee thanks the exhibitors for their support of the annual symposium.
The Second DAPSOC Symposium entitled ‘Analysis of protein complexes: Purification, interaction, dynamics’ was held on December 5, 2006 at the University of Southern Denmark.
Ole N. Jensen welcomed the speakers and attendees and gave a short introduction of the activities of DAPSOC, EuPA and HUPO. Speakers included Carol V. Robinson (Cambridge, UK) who described her outstanding work on protein complexes and subunit architecture using electrospray ionization mass spectrometry. , Thomas Jørgensen (Univ. Southern Denmark) described how to use hydrogen/deuterium exchange and mass spectrometry to study protein stability, folding and interactions and the attempts to circumvent ‘scrambling’ of deuterons during MS/MS. Hans Peter Braun (Univ. Hannover, D) gave a very nice overview of the use of blue native gel electrophoresis to study plant organelles and protein complexes and Niels Heegaard (Statens Serum Institute) described a new approach for biomarker discovery that is targeting circulating microparticles in blood. Henning Urlaub (MPI Biophysics, Göttingen, D) described recent work on structure/function studies of protein-RNA complexes using UV cross-linking and mass spectrometry. Jens S. Andersen (SDU) presented a talk on organellar proteomics using both quantitative mass spectrometry and fluorescence microscopy to study the dynamics of large protein complexes in the nucleus. Finally, Bernhard Küster (Cellzome, D) introduced the ‘Kinobeads’ based approach for affinity-based enrichment of human protein kinases and described how this method can be used in drug discovery to identify drug targets using proteomics technologies.
The auditorium was completely full (>90 persons) attesting to the interest in the topics covered by the speakers. A total of ten companies presented their products and tools for proteomics. This year, DAPSOC provided sandwiches and drinks for free during a combined lunch/exhibition/poster session that was a great success. Many participants provided positive feedback and suggestions.
The First DAPSOC Symposium ‘Phosphoproteomics and Cell Signaling‘ was held on Dec. 8, 2005, at the University of Southern Denmark. More than 70 attendees from industry, academia and national laboratories were gathered for a full day symposium that featured international and Danish speakers. Dr. Albert Sickmann (Würzburg, D) presented novel proteomic strategies for the analysis of platelet membrane proteins and Dr. Jeroen Krijgsveld (Utrecht, NL) described mass spectrometry approaches for quantitative proteomic analysis of the fruit fly and embryonic stem cells. In a fascinating closing lecture, Dr. Lars Juhl Jensen (EMBL, D) outlined current bioinformatics approaches to investigate protein interaction networks. Additional speakers were Drs. Blagoy Blagoev, Albrecht Gruhler, Thomas Kledal, Tia Sorsa, Majbrit Hjerrild and Martin R. Larsen. The excellent scientific presentations and the lively discussions among the delegates made this symposium a very successful kick-off event for DAPSOC. The support from more than 10 vendors was greatly appreciated. |
